Testimonials and Citations

Testimonials and Citations

What scientists are saying about Avalanche® Transfection Reagents

“Ease Of Use”

“I must say I like this system (Avalanche®), especially its ease of use and the fact that I do not need to change the media anytime after transfection.”

E Udho, Ph.D

NIH/NINDS

Higher Efficiency Than Nucleofection

LA-N-2 neuroblastoma, Ptracer-SV40 (GFP)
Avalanche®: 35% at optimal ratio (1.5 ul/2.5 ul DNA in a six well plate); Nucleofection: 31% 

C Kaneski, Ph.D

NIH/NINDS

Human Lymphocyte High Efficiency
Transfection

“Thanks again for bringing to our lab an efficient transfection reagent that worked on our difficult to transfect BJAB cell line. Results showed Avalanche® reagent to be 10X more efficient than lipofectamine and DharmaFect. We finally have the conditions to work with this cell line by using the Avalanche® Transfection Reagent”

A Fernandez, Ph.D.

NIH

Huge Differences

Tet—On Inducible NSC34 Cells, shRNA rescue by transfecting RNAi Resistant cDNA cloned into an expression vector. EGFP control plasmid,  Avalanche® efficiency 50—60%, Lipofectamine 2000/Less Than 10%, Lipofectamine 3000/Less Than 10%

C Peter, Assistant Professor

Icahn School of Medicine at Mount Sinai

“It Worked Like A Charm.”

Mouse cementoblast OCCm-30 cells. Control plasmid, YFP-N1 plasmid
Avalanche®: 80-90%; Lipofectsamine 2000: 5-10%,
“There was slight toxicity, but it worked like a charm.”

N Bhattacharyya, Ph.D.

NIH

Great On Primary Neuron Transfection

” I tested Avalanche® on primary cortical neurons and it worked much better than any other transfection reagents I’ve ever tried.”

A Caputo, PhD

David Geffen School of Medicine at UCLA

“The Readings Were So High That Most
Wells Had Overflow Readings”

“I got huge transfection efficiency (on using Avalanche®)! I am using HEKs for BRET ( like FRET but with Renilla as the donor molecule) assays and I am reading Renilla substrate and GFP excitation using a Biotek plate reader. The readings were so high that most wells had overflow readings. I was doing the same assay with Fugene transfected HEK cells an none of the wells were even close to overflow. This means that not just by looking at the microscope but even by a more precise reading at the plate reader your reagent is much superior. So now I have to scale down the amount of plasmids I transfect in HEKs because reagent is just too good!”

E Pinceti, PhD

Loyola University Chicago

C2C12 cells showed big differences between avalanche® and Lipofectamine™ 2000

--- C Rhodes, Ph.D. NIH/NIDCR

EZ Biosystems™ encourage and welcomes feedback from scientists in both academia and industry on how to continue to meet the needs and expectations of the life science community.

The following is a selection of the latest relevant references using Avalanche® Transfection Reagents

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Cell
or
Animal
in vivo
or
in vitro

Delivered
Molecule


Reagent


Results & Citations
DU 145
PC-3
in vitro
plasmid
EZT-DU14-1
More Details
S. Akamatsu. et al.,
2015
Cell Rep
12,
(6):
922-36
The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer
WI-38
in vitro
plasmid
EZT-WI38-1
More Details
M. Milewska. et al.,
2014
Cell Signal
26,
(9):
1870-7
Mig-6 participates in the regulation of cell senescence and retinoblastoma protein phosphorylation
HEK-293T
Hela
Human fibroblast
hTERT RPE-1
in vitro
plasmid
EZT-OMNI-1
More Details
J. Chang. et al.,
2014
J Clin Invest
124,
(12):
5249-62
Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation
skMC
KD3
primary human myoblasts
immortalized human myogenic cell
in vitro
plasmid
EZT-HSKM-1
More Details
F. Nasrin. et al.,
2014
Sci Rep
4,
():
6841
HnRNP C, YB-1 and hnRNP L coordinately enhance skipping of human MUSK exon 10 to generate a Wnt-insensitive MuSK isoform
Jurkat
in vitro
plasmid
EZT-MOLT-1
More Details
D. Hnisz. et al.,
2016
Science
351,
(6280):
1454-1458
Activation of proto-oncogenes by disruption of chromosome neighborhoods
IGROV-1
SK-OV-3
in vitro
plasmid
EZT-IGRO-1
More Details
L. Batista. et al.,
2016
Nat Commun
7,
():
8959
Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through
human preadipocyte
in vitro
plasmid
EZT-HPAD-1
More Details
S. Chen. et al.,
2016
Arterioscler Thromb Vasc Biol
36,
(8):
1651-9
Vitamin D Deficiency Accelerates Coronary Artery Disease Progression in Swine
SF268
in vitro
plasmid
EZT-S268-1
More Details
C. Stein. et al.,
2015
PLoS Genet
11,
(8):
e1005465
YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers
1205Lu
Human Metastatic Melanoma Cell
in vitro
plasmid
EZT-OMNI-1
More Details
J. L. Osborn. et al.,
2015
Int J Mol Sci
16,
(2):
4343-61
Metastatic melanoma cells evade immune detection by silencing STAT1
Hela
BE(2)-M17
neurobalstoma cell
HEK-293T
in vitro
plasmid
gRNA
EZT-OMNI-1
More Details
C. L. Nezich. et al.,
2015
J Cell Biol
210,
(3):
435-50
MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5
HEK-293T
Hela
in vitro
plasmid
EZT-OMNI-1
More Details
M. Lazarou. et al.,
2015
Nature
524,
(7565):
309-314
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
RBL-2H3
in vitro
plasmid
EZT-RBL2-1
More Details
S. Liu. et al.,
2016
Sci Rep
6,
():
28133
CRACM3 regulates the stability of non-excitable exocytotic vesicle fusion pores in a Ca(2+)-independent manner via molecular interaction with syntaxin4
A549
in vitro
plasmid
EZT-OMNI-1
More Details
T. Toyotome. et al.,
2016
J Toxicol Sci
41,
(1):
25-31
MEIS3 is repressed in A549 lung epithelial cells by deoxynivalenol and the repression contributes to the deleterious effect
HEK-293T
hTERT-RPE1
in vitro
plasmid
EZT-OMNI-1
More Details
S. Lee. et al.,
2016
Nat Commun
7,
():
10939
FAM21 directs SNX27-retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus
HEp-2
in vitro
plasmid
EZT-OMNI-1
More Details
S. J. Jadhao. et al.,
2016
Methods Mol Biol
1442,
():
41-52
Detection of RSV Antibodies in Human Plasma by Enzyme Immunoassays
MEF
mouse primary neuron
NIH-3T3
COS7
in vitro
plasmid
EZT-OMNI-1
More Details
B. Renvoise. et al.,
2016
Hum Mol Genet
25,
(23):
5111-5125
Reep1 null mice reveal a converging role for hereditary spastic paraplegia proteins in lipid droplet regulation
OCCM-30
in vitro
plasmid
EZT-OCCM-1
More Details
Y. Y. Zhang. et al.,
2016
Chin J Dent Res
19,
(2):
103-8
Osteoprotegerin Promotes Cementoblastic Activity of Murine Cementoblast Cell Line in vitro
MRC-5
in vitro
plasmid
EZT-MRC5-1
More Details
T. Lear. et al.,
2016
J Exp Med
213,
(6):
1029-46
Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4
MRC-5
in vitro
siRNA
EZT-MRC5-1
More Details
T. Goullet de Rugy. et al.,
2016
Biol Open
5,
(10):
1485-1492
Excess Poltheta functions in response to replicative stress in homologous recombination-proficient cancer cells
HDF
Human Dermal Fibroblast
in vitro
plasmid
EZT-HDF0-1
More Details
R. K. Seong. et al.,
2017
Immunobiology
222,
(11):
979-988
Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication
HDF
MeWo melanoma cells
HEK-293T
MRC-5
human fetal fibroblast
in vitro
plasmid
EZT-HDF0-1
More Details
J. A. Kim. et al.,
2017
J Invest Dermatol
137,
(10):
2101-2109
STING Is Involved in Antiviral Immune Response against VZV Infection via the Induction of Type I and III IFN Pathways
COS-7
in vitro
plasmid
EZT-COS7-1
More Details
D. B. Peckys. et al.,
2017
J Struct Biol
199,
(2):
102-113
The stoichiometry of the TMEM16A ion channel determined in intact plasma membranes of COS-7 cells using liquid-phase electron microscopy
HEK-293
COS-7
in vitro
plasmid
EZT-COS7-1
More Details
L. Hofmann. et al.,
2017
Cell Calcium
63,
():
24-28
A conserved gating element in TRPV6 channels
bEnd3.1
in vitro
siRNA
EZT-BEND-1
More Details
S. A. Sonar. et al.,
2017
Immunol Cell Biol
95,
(9):
843-853
IFN-gamma promotes transendothelial migration of CD4(+) T cells across the blood-brain barrier
4T1
in vitro
plasmid
EZT-4T10-1
More Details
R. Garcia-Areas. et al.,
2017
Int J Oncol
51,
(5):
1395-1404
Suppression of tumor-derived Semaphorin 7A and genetic ablation of host- derived Semaphorin 7A impairs tumor progression in a murine model of advanced breast carcinoma
Mouse
in vivo
shRNA
EZT-VIVO-1
More Details
K. S. Baghel. et al.,
2016
Oncoimmunology
5,
(7):
e1196299
Macrophages promote matrix protrusive and invasive function of breast cancer cells via MIP-1beta dependent upregulation of MYO3A gene in breast cancer cells
Ishikawa
endometrial adenocarcinoma
in vitro
plasmid
EZT-OVC8-1
More Details
J. J. Wallbillich. et al.,
2017
PLoS One
12,
(1):
e0170318
High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer
NIH:OVCAR-3
in vitro
plasmid
EZT-OVC3-1
More Details
N. E. Saidu. et al.,
2017
Mol Cancer Ther
16,
(3):
529-539
Dimethyl Fumarate Controls the NRF2/DJ-1 Axis in Cancer Cells: Therapeutic Applications
U251
SNB19
T98G
U87
in vitro
siRNA
EZT-OMNI-1
More Details
Y. Dong. et al.,
2017
Oncotarget
8,
(67):
111728-111741
Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug
OCCM-30
in vitro
siRNA
EZT-OCCM-1
More Details
Y. Y. Zhang. et al.,
2017
Angle Orthod
87,
(4):
618-624
Cementogenesis is inhibited under a mechanical static compressive force via Piezo1
Jurkat
in vitro
plasmid
EZT-MOLT-1
More Details
B. J. Abraham. et al.,
2017
Nat Commun
8,
():
14385
Small genomic insertions form enhancers that misregulate oncogenes
MDCK
in vitro
plasmid
EZT-MDCK-1
More Details
A. J. Trease. et al.,
2017
J Mol Cell Cardiol
111,
():
69-80
Intramolecular signaling in a cardiac connexin: Role of cytoplasmic domain dimerization
n/a
in vitro
n/a
EZT-HT29-1
More Details
B. Niemann. et al.,
2017
Mol Nutr Food Res
61,
(12):
Folic acid modulates cancer-associated micro RNAs and inflammatory mediators in neoplastic and non-neoplastic colonic cells in a different way
OCCM-30
in vitro
plasmid
EZT-OCCM-1
More Details
H. Zhao. et al.,
2018
J Cell Biochem
119,
(7):
5725-5733
Nell-1-DeltaE, a novel transcript of Nell-1, inhibits cell migration by interacting with enolase-1
Neuro-2a
in vitro
plasmid
EZT-NEUR-1
More Details
B. E. Hall. et al.,
2018
Sci Rep
8,
(1):
1177
Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin- dependent Kinase 5 affects Chemo-nociception
MEF
in vitro
plasmid
EZT-MEFS-1
More Details
J. Lebeau. et al.,
2018
Cell Rep
22,
(11):
2827-2836
The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress
huPASMC
human pulmonary artery smooth muscle cell
in vitro
plasmid
EZT-HAOS-1
More Details
D. Zabini. et al.,
2018
Am J Respir Crit Care Med
197,
(2):
244-260
Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition
MCF-7
SK-BR-3
T47D
in vitro
plasmid
EZT-EVDY-1
More Details
K. Takagi. et al.,
2018
Int J Mol Sci
19,
(3):
ARHGAP15 in Human Breast Carcinoma: A Potent Tumor Suppressor Regulated by Androgens
A-431
in vitro
plasmid
EZT-A431-1
More Details
S. Wang. et al.,
2018
Nucleic Acids Res
46,
(7):
3579-3594
Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides
HEK-293
in vitro
plasmid
EZT-2930-1
More Details
M. Amini. et al.,
2019
iScience
11,
():
12-Jan
Identification of Inhibitory Ca(2+) Binding Sites in the Upper Vestibule of the Yeast Vacuolar TRP Channel
T47D
in vitro
plasmid
gRNA
EZT-T47D-1
More Details
M. Soni. et al.,
2018
Mol Cancer Res
16,
(9):
1348-1360
Autophagy, Cell Viability, and Chemoresistance Are Regulated By miR-489 in Breast Cancer
GK1.5
hybridoma cells
in vitro
plasmid
EZT-SPAG-1
More Details
A. Wieland. et al.,
2018
Sci Immunol
3,
(27):
Enhancing FcgammaR-mediated antibody effector function during persistent viral infection
ARPE-19
in vitro
plasmid
siRNA
EZT-OVC3-1
More Details
N. E. Bennett Saidu. et al.,
2018
Oncotarget
9,
(10):
9088-9099
Dimethyl fumarate is highly cytotoxic in KRAS mutated cancer cells but spares non-tumorigenic cells
HEK-293
in vitro
plasmid
EZT-OMNI-1
More Details
Y. Katagiri. et al.,
2018
J Biol Chem
293,
(29):
11639-11647
Identification of novel binding sites for heparin in receptor protein- tyrosine phosphatase (RPTPsigma): Implications for proteoglycan signaling
HMEC-1
immortalized human microvascular endothelial cell
in vitro
plasmid
EZT-OMNI-1
More Details
M. C. Harwig. et al.,
2018
Anal Biochem
552,
():
81-99
Methods for imaging mammalian mitochondrial morphology: A prospective on MitoGraph
Hs 683
human brain glioma fibroblast
in vitro
plasmid
EZT-OMNI-1
More Details
E. T. Ajuh. et al.,
2018
J Virol
92,
(7):
Novel Human Polyomavirus Noncoding Control Regions Differ in Bidirectional Gene Expression according to Host Cell, Large T-Antigen Expression, and Clinically Occurring Rearrangements
Plat-E
in vitro
plasmid
EZT-OMNI-1
More Details
T. Maruhashi. et al.,
2018
Nat Immunol
19,
(12):
1415-1426
LAG-3 inhibits the activation of CD4(+) T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII
HEK-293
HeLa
in vitro
plasmid
siRNA
EZT-OMNI-1
More Details
Y. Takanezawa. et al.,
2019
Toxicol Sci
170,
(2):
438-451
Intracellular Demethylation of Methylmercury to Inorganic Mercury by Organomercurial Lyase (MerB) Strengthens Cytotoxicity
SAEC
human small airway epithelial cell
in vitro
MiRNA
MIr-126
EZT-HBEC-1
More Details
Y. Zhou. et al.,
2019
Crit Care
23,
(1):
44
Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury
3T3-L1
in vitro
plasmid
EZT-EVDY-1
More Details
H. Tawarayama. et al.,
2019
Invest Ophthalmol Vis Sci
60,
(13):
4479-4488
Cyclin-Dependent Kinase Inhibitor 2b Mediates Excitotoxicity-Induced Death of Retinal Ganglion Cells
HEK-293
in vitro
plasmid
EZT-EVDY-1
More Details
X. Wang. et al.,
2019
J Biol Chem
294,
(43):
15733-15742
REV7 has a dynamic adaptor region to accommodate small GTPase RAN/Shigella IpaB ligands, and its activity is regulated by the RanGTP/GDP switch
Hela
in vitro
plasmid
EZT-EVDY-1
More Details
N. Nakai. et al.,
2019
Microscopy (Oxf)
68,
(5):
359-368
Genetically encoded orientation probes for F-actin for fluorescence polarization microscopy
HEK-293T
in vitro
plasmid
EZT-EVDY-1
More Details
K. Kitao. et al.,
2019
J Gen Virol
100,
(4):
662-668
Identification of a post-transcriptional regulatory element in the human endogenous retroviral syncytin-1
WPMY-1
human prostate myofibroblast stromal cell
in vitro
siRNA
EZT-PRSC-1
More Details
Q. Yu. et al.,
2019
J Biol Chem
294,
(32):
12231-12249
A NAV2729-sensitive mechanism promotes adrenergic smooth muscle contraction and growth of stromal cells in the human prostate
PC-12
in vitro
plasmid
EZT-PC12-1
More Details
J. Benicky. et al.,
2019
J Biol Chem
294,
(45):
16816-16830
N-Glycosylation is required for secretion of the precursor to brain- derived neurotrophic factor (proBDNF) carrying sulfated LacdiNAc structures
PANC-1
in vitro
plasmid
EZT-PANC-1
More Details
M. Tandon. et al.,
2019
Cancer Res
79,
(20):
5316-5327
Prolactin Promotes Fibrosis and Pancreatic Cancer Progression
HEK-293T
in vitro
plasmid
EZT-OMNI-1
More Details
T. Y. Liu. et al.,
2019
Front Mol Neurosci
12,
():
302
Two Vanilloid Ligand Bindings Per Channel Are Required to Transduce Capsaicin-Activating Stimuli
HEK-293T
Plat-E
in vitro
plasmid
EZT-OMNI-1
More Details
D. Sugiura. et al.,
2019
Science
364,
(6440):
558-566
Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses
HeLa
NIH-3T3
U-2 OS
in vitro
plasmid
EZT-OMNI-1
More Details
E. Greenberg. et al.,
2019
Nucleic Acids Res
47,
(18):
e109
Cytoplasmic DNA can be detected by RNA fluorescence in situ hybridization
Plat-E
in vitro
plasmid
EZT-OMNI-1
More Details
T. K. Maeda. et al.,
2019
J Biol Chem
294,
(15):
6017-6026
Atypical motifs in the cytoplasmic region of the inhibitory immune co- receptor LAG-3 inhibit T cell activation
MDA-MB-157
MCF10A
in vitro
siRNA
EZT-EVDY-1
More Details
N. Pernicone. et al.,
2020
Anticancer Res
40,
(10):
5471-5480
MDA-MB-157 Cell Line Presents High Levels of MAD2L2 and Dysregulated Mitosis
HEK-293
in vitro
plasmid
EZT-EVDY-1
More Details
N. Pernicone. et al.,
2020
Biochem Biophys Res Commun
531,
(4):
566-572
CDH1 binds MAD2L2 in a Rev1-like pattern
OVCA433
in vitro
plasmid
EZT-EVDY-1
More Details
N. Filippov-Levy. et al.,
2020
Anticancer Res
40,
(12):
6677-6684
The Biological Role of the Long Non-coding RNA LINK-A in Ovarian Carcinoma
OVCAR8
in vitro
plasmid
EZT-EVDY-1
More Details
N. Filippov-Levy. et al.,
2020
Int J Mol Sci
21,
(15):
The Biological and Clinical Role of the Long Non-Coding RNA LOC642852 in Ovarian Carcinoma
Mouse
in vivo
plasmid
EZT-VIVO-1
More Details
A. G. Herbert. et al.,
2019
,
(PCT / US2019 / 057993):
METHODS AND COMPOSITIONS TO INDUCE OR SUPPRESS IMMUNE RESPONSES THROUGH THE USE OF MEMBRANE BOUND COMPLEMENT SPLIT PRODUCTS
Mouse
in vivo
siRNA
EZT-VIVO-1
More Details
H. Shimoda. et al.,
2019
Kidney Int
96,
(5):
1162-1175
Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16(INK4a)
T84
in vitro
siRNA
EZT-T840-1
More Details
N. Makhezer. et al.,
2019
Mucosal Immunol
12,
(1):
117-131
NOX1-derived ROS drive the expression of Lipocalin-2 in colonic epithelial cells in inflammatory conditions
Neuro-2a
in vitro
plasmid
EZT-OMNI-1
More Details
S. Tilve. et al.,
2020
Exp Cell Res
389,
(2):
111911
Phospholipid phosphatase related 1 (PLPPR1) increases cell adhesion through modulation of Rac1 activity
U251
SNB19
T98G
A172
in vitro
siRNA
EZT-OMNI-1
More Details
J. Zhang. et al.,
2020
Cancer Sci
111,
(7):
2413-2422
Gelsolin inhibits malignant phenotype of glioblastoma and is regulated by miR-654-5p and miR-450b-5p
MDCK
in vitro
plasmid
EZT-MDCK-1
More Details
K. Tanaka. et al.,
2020
Biochem Biophys Res Commun
,
():
Ubiquitination of Src promotes its secretion via small extracellular vesicles
L6
in vitro
plasmid
EZT-L600-1
More Details
S. I. Stone. et al.,
2020
J Endocr Soc
4,
(12):
bvaa138
Digenic Variants in the FGF21 Signaling Pathway Associated with Severe Insulin Resistance and Pseudoacromegaly
HL-60
in vitro
plasmid
EZT-HL60-1
More Details
Y. Li. et al.,
2020
EMBO Rep
21,
(8):
e48779
Nuclear envelope rupture and NET formation is driven by PKCalpha-mediated lamin B disassembly
NHBE
Primary normal human bronchial epithelial cell
in vitro
plasmid
EZT-HBEC-1
More Details
K. Oniki. et al.,
2020
Sci Rep
10,
(1):
5973
The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties
BmN
insect cell
in vitro
bacmid
EZT-EVDY-1
More Details
R. Fujita. et al.,
2020
Biochem Biophys Res Commun
529,
(2):
257-262
Efficient production of recombinant SARS-CoV-2 spike protein using the baculovirus-silkworm system
RBL-2H3
in vitro
plasmid
EZT-RBL2-1
More Details
Y. Suzuki. et al.,
2020
Eur J Pharmacol
878,
():
173104
A novel MRGPRX2-targeting antagonistic DNA aptamer inhibits histamine release and prevents mast cell-mediated anaphylaxis
RBL-2H3
in vitro
plasmid
EZT-RBL2-1
More Details
M. N. A. Sahid. et al.,
2020
Inflamm Res
69,
(3):
289-298
Tachykinin-1 receptor antagonism suppresses substance-P- and compound 48/80-induced mast cell activation from rat mast cells expressing functional mas-related GPCR B3
MCF 10A
hTERT RPE-1
B16-F10
HCT116
in vitro
5'ppp-dsRNA
2'3'-cGAMP
EZT-OMNI-1
More Details
J. Chen. et al.,
2020
Cell Rep
32,
(9):
108080
Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses
HEK-293T
in vitro
plasmid
EZT-OMNI-1
More Details
Y. Chu. et al.,
2020
Sci Rep
10,
(1):
8038
A single TRPV1 amino acid controls species sensitivity to capsaicin
HEK-293T
in vitro
plasmid
EZT-OMNI-1
More Details
C. J. Goetz. et al.,
2020
Bioorg Chem
104,
():
104232
Development of activity-based probes for the protein deacylase Sirt1
HEK-293
in vitro
plasmid
EZT-OMNI-1
More Details
S. L. Higashi. et al.,
2020
J Biochem
168,
(3):
313
Old but not obsolete: an enhanced high-speed immunoblot
CRFK
Felis catus
cat kidney cell
in vitro
plasmid
EZT-EVDY-1
More Details
S. Aso. et al.,
2021
Microbes Environ
36,
(4):
Identification of Feline Foamy Virus-derived MicroRNAs
Hela
U-2 OS
U251MG
in vitro
plasmid
EZT-EVDY-1
More Details
Y. Kamikawa. et al.,
2021
Cell Death Discov
7,
(1):
152
OASIS/CREB3L1 is a factor that responds to nuclear envelope stress
MEF
HEK-293
in vitro
plasmid
EZT-EVDY-1
More Details
K. Terasawa. et al.,
2021
Autophagy
17,
(12):
4286-4304
Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells
T47D
MCF-7
MDA-MB-231
in vitro
plasmid
EZT-EVDY-1
More Details
C. Hayashi. et al.,
2021
Histol Histopathol
36,
(10):
1053-1062
D-2-hydroxyglutarate dehydrogenase in breast carcinoma as a potent prognostic marker associated with proliferation
293T
CEF
chick embryonic fibroblast
LMH
in vitro
plasmid
EZT-EVDY-1
More Details
T. Kudo. et al.,
2021
The Shujitsu University journal of pharmaceutical sciences
8,
(7565):
37
The chicken homolog of KIAA0319L functions as a receptor of avian adeno-associated virus (A3V)
Daoy
human brain Desmoplastic Cerebellar Medulloblastoma cell line
in vitro
siRNA
EZT-EVDY-1
More Details
S. Gershanov. et al.,
2021
Cancer Genomics Proteomics
18,
(3):
335-347
Differences in RNA and microRNA Expression Between PTCH1- and SUFU-mutated Medulloblastoma
U251
in vitro
plasmid
EZT-U251-1
More Details
V. Turri. et al.,
2020
Biomed Res Int
2020,
():
7465242
Cauliflower Mosaic Virus TAV, a Plant Virus Protein That Functions like Ribonuclease H1 and is Cytotoxic to Glioma Cells
HeLa
in vitro
plasmid
EZT-OMNI-1
More Details
J. W. Kim. et al.,
2021
Cells
10,
(1):
Identification of Cathepsin D as a Plasma Biomarker for Alzheimer's Disease
HGrC1
human nonluteinized granulosa cell line from human ovary
in vitro
plasmid
EZT-OMNI-1
More Details
Y. Kasahara. et al.,
2021
Cell Death Discov
7,
(1):
186
Primate-specific POTE-actin gene could play a role in human folliculogenesis by controlling the proliferation of granulosa cells
Neuro-2a
in vitro
plasmid
EZT-OMNI-1
More Details
C. Agbaegbu Iweka. et al.,
2021
J Neurochem
157,
(3):
494-507
The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules
NIH-3T3
in vitro
plasmid
EZT-OMNI-1
More Details
C. M. Kelly. et al.,
2021
J Cell Biol
220,
(11):
The hypervariable region of atlastin-1 is a site for intrinsic and extrinsic regulation
HepG2
in vitro
siRNA
EZT-OMNI-1
More Details
T. Nakamura. et al.,
2021
Shimane Journal of Medical Science
38,
(2):
59
Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells
MDCK
in vitro
plasmid
EZT-MDCK-1
More Details
K. Kajiwara. et al.,
2021
Life Sci Alliance
4,
(4):
CDCP1 promotes compensatory renal growth by integrating Src and Met signaling
BmN
insect cell
Bombyx mori-derived cell
Silkworm cell
in vitro
bacmid
EZT-EVDY-1
More Details
H. Ohga. et al.,
2021
Cells
10,
(12):
Leptin Is an Important Endocrine Player That Directly Activates Gonadotropic Cells in Teleost Fish, Chub Mackerel
BmN
insect cell
Bombyx mori-derived cell
Silkworm cell
in vitro
bacmid
EZT-EVDY-1
More Details
T. Ebihara. et al.,
2021
Mol Biotechnol
63,
(12):
1223-1234
Production of scFv, Fab, and IgG of CR3022 Antibodies Against SARS-CoV-2 Using Silkworm-Baculovirus Expression System
293T
in vitro
plasmid
EZT-EVDY-1
More Details
K. Kitao. et al.,
2021
Retrovirology
18,
(1):
36
An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation
4T1
in vitro
plasmid
EZT-4T10-1
More Details
L. Nebot-Bral. et al.,
2022
J Immunother Cancer
10,
(7):
15-Jan
Overcoming resistance to alphaPD-1 of MMR-deficient tumors with high tumor-induced neutrophils levels by combination of alphaCTLA-4 and alphaPD-1 blockers
Rat
in vivo
plasmid
EZT-VIVO-1
More Details
O. Gawrys. et al.,
2021
Biochem Genet
59,
(1):
62-82
Polyprenol-Based Lipofecting Agents for In Vivo Delivery of Therapeutic DNA to Treat Hypertensive Rats
U-2 OS
Hela
in vitro
plasmid
EZT-U2OS-1
More Details
S. Gaillard. et al.,
2021
Biol Open
10,
(5):
KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance
WPMY-1
human prostate myofibroblast stromal cell
in vitro
plasmid
EZT-PRSC-1
More Details
R. Wang. et al.,
2021
Mol Pharmacol
100,
(4):
356-371
ADP Ribosylation Factor 6 Promotes Contraction and Proliferation, Suppresses Apoptosis and Is Specifically Inhibited by NAV2729 in Prostate Stromal Cells
THP1
in vitro
gRNA
EZT-OMNI-1
More Details
T. Nakatani. et al.,
2021
Nat Commun
12,
(1):
3333
The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II
EL4
Th0
polarized Th1
Th17
in vitro
plasmid
EZT-EL40-1
More Details
Y. W. Liu. et al.,
2022
JCI Insight
,
():
Blimp-1 moulds the epigenetic architecture of IL-21-mediated autoimmune diseases through an autoregulatory circuit
CT26.WT
in vitro
plasmid
EZT-CT26-1
More Details
I. M. Fareez. et al.,
2022
Probiotics Antimicrob Proteins
,
():
Chemoprevention by Microencapsulated Lactiplantibacillus Plantarum LAB12 Against Orthotopic Colorectal Cancer Mice is Associated with Apoptosis and Anti-angiogenesis
C8-D30
in vitro
plasmid
EZT-CRPR-1
More Details
A. Nasuhidehnavi. et al.,
2022
Infect Immun
90,
(8):
e0020522
A Role for Basigin in Toxoplasma gondii Infection
COS-7
in vitro
plasmid
EZT-COS7-1
More Details
A. Belkacemi. et al.,
2022
Cell Calcium
104,
():
102573
IP3-dependent Ca(2+) signals are tightly controlled by Cavbeta3, but not by Cavbeta1, 2 and 4
C2C12
in vitro
plasmid
siRNA
EZT-C2C1-1
More Details
I. Cocchiararo. et al.,
2022
Exp Cell Res
421,
(2):
113392
Back to basics: Optimization of DNA and RNA transfer in muscle cells using recent transfection reagents
HEK-293T
COS-7
Hela
RPE1
in vitro
plasmid
siRNA
EZT-EVDY-1
EZT-OMNI-1
More Details
P. Zheng. et al.,
2022
Nature
601,
(7891):
132-138
ER proteins decipher the tubulin code to regulate organelle distribution
HEK-293
in vitro
plasmid
EZT-EVDY-1
More Details
S. Fujiwara. et al.,
2022
Ann N Y Acad Sci
1516,
(1):
85-94
Tight junction formation by a claudin mutant lacking the COOH-terminal PDZ domain-binding motif
Hela
A549
MCF7
in vitro
plasmid
EZT-EVDY-1
More Details
N. Funato. et al.,
2022
Sci Rep
12,
(1):
20188
TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties
MC3T3-E1
in vitro
plasmid
EZT-EVDY-1
More Details
H. Sugimoto. et al.,
2022
Biochem Biophys Res Commun
635,
():
203-209
Visualization of osteocalcin and bone morphogenetic protein 2 (BMP2) secretion from osteoblastic cells by bioluminescence imaging
OVCAR3
OVCAR8
in vitro
plasmid
EZT-EVDY-1
More Details
H. Onallah. et al.,
2022
Int J Mol Sci
23,
(21):
Exosome Secretion and Epithelial-Mesenchymal Transition in Ovarian Cancer Are Regulated by Phospholipase D
silkworm
in vitro
plasmid
EZT-EVDY-1
More Details
M. Hino. et al.,
2022
Insects
13,
(7):
Characterization of a Novel Heterochromatin Protein 1 Homolog HP1c" in the Silkworm, Bombyx mori"
silkworm
in vitro
plasmid
EZT-EVDY-1
More Details
H. Mon. et al.,
2022
Insect Biochem Mol Biol
151,
():
103875
Construction of gene co-expression networks in cultured silkworm cells and identification of previously uncharacterized lepidopteran-specific genes required for chromosome dynamics
HMLE
HMEC
Human mammary epithelial cell
in vitro
PiggyBac
EZT-HMEC-1
More Details
L. Richart. et al.,
2022
Cell
,
():
XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation
HL-60
in vitro
plasmid
EZT-HL60-1
More Details
S. Taylor. et al.,
2022
Am J Respir Crit Care Med
,
():
Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension
Hepa 1-6
in vitro
siRNA
EZT-HEPA-1
More Details
L. Zhang. et al.,
2022
Nucleic Acid Ther
32,
(4):
280-299
NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides
B16-F1
WM266.4
HeLa
HEK-293
in vitro
plasmid
EZT-EVDY-1
More Details
R. Hernandez-Vicens. et al.,
2022
Cell Prolif
55,
(12):
e13348
SETDB1 regulates microtubule dynamics
BmN4-SID1
Bombyx mori
Silk moth
in vitro
plasmid
EZT-EVDY-1
More Details
M. Tanaka. et al.,
2022
Insect Biochem Mol Biol
143,
():
103737
Silkworm FoxL21 plays important roles as a regulator of ovarian development in both oogenesis and ovariole development
CRFK
Felis catus
cat kidney cell
in vitro
plasmid
EZT-EVDY-1
More Details
A. Sumiyoshi. et al.,
2022
J Vet Med Sci
84,
(1):
157-165
Genetic and biological characterization of feline foamy virus isolated from a leopard cat (Prionailurus bengalensis) in Vietnam
HEK-293
in vitro
plasmid
EZT-EVDY-1
More Details
N. Pernicone. et al.,
2022
Molecules
27,
(3):
Disrupting the MAD2L2-Rev1 Complex Enhances Cell Death upon DNA Damage
INS 832/13
in vitro
plasmid
EZT-OMNI-1
More Details
J. A. Nord. et al.,
2022
Front Endocrinol (Lausanne)
13,
():
923925
N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic beta- cells
Neuro-2a
in vitro
plasmid
EZT-OMNI-1
More Details
C. P. Mencio. et al.,
2022
PLoS One
17,
(6):
e0269972
A novel cytoskeletal action of xylosides
Plat-E
HEK-293T
in vitro
plasmid
EZT-OMNI-1
More Details
D. Sugiura. et al.,
2022
Nat Immunol
23,
(3):
399-410
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity
U-2 OS
in vitro
plasmid
EZT-OMNI-1
More Details
D. J. Byrne. et al.,
2022
Acta Neuropathol Commun
10,
(1):
40
Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia
L6
in vitro
plasmid
EZT-L600-1
More Details
K. E. Merz. et al.,
2022
Front Endocrinol (Lausanne)
13,
():
821849
Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis
L6
skeletal muscle myoblast
in vitro
plasmid
EZT-L600-1
More Details
K. E. Merz. et al.,
2022
Nat Commun
13,
(1):
424
Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1
n/a
in vitro
n/a
n/a
More Details
S. Liu. et al.,
2023
Mol Cell
83,
(9):
1502-1518 e10
The mechanism of STING autoinhibition and activation
U251
in vitro
plasmid
EZT-U251-1
More Details
C. H. Lipper. et al.,
2022
Structure
30,
(2):
206-214 e4
Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site
T84
in vitro
plasmid
EZT-T840-1
More Details
D. Liu. et al.,
2022
Cell Mol Gastroenterol Hepatol
13,
(4):
1073-1093
Protein Kinase CK2 Acts as a Molecular Brake to Control NADPH Oxidase 1 Activation and Colon Inflammation
T47D
in vitro
plasmid
gRNA
EZT-T47D-1
More Details
M. Soni. et al.,
2022
Int J Mol Sci
23,
(15):
miR-489 Confines Uncontrolled Estrogen Signaling through a Negative Feedback Mechanism and Regulates Tamoxifen Resistance in Breast Cancer
786-O
in vitro
plasmid
EZT-OMNI-1
More Details
F. Chesnel. et al.,
2022
Br J Cancer
127,
(11):
1954-1962
Mutation of the proline P81 into a serine modifies the tumour suppressor function of the von Hippel-Lindau gene in the ccRCC
HeLa
in vitro
plasmid
EZT-OMNI-1
More Details
K. Nakane. et al.,
2022
Int J Mol Sci
23,
(19):
Switching of Photocatalytic Tyrosine/Histidine Labeling and Application to Photocatalytic Proximity Labeling
HMEC-1
ARPE–19
HeLa
in vitro
plasmid
EZT-OMNI-1
More Details
J. M. Egner. et al.,
2022
J Biol Chem
298,
(12):
102620
Structural studies of human fission protein FIS1 reveal a dynamic region important for GTPase DRP1 recruitment and mitochondrial fission
U251MG
U87MG
NP5
LN229
fibroblast
in vitro
plasmid
EZT-EVDY-1
More Details
A. Saito. et al.,
2023
Cell Rep
42,
(5):
112479
p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS
A549
SK-N-SH
in vitro
plasmid
EZT-A549-1
EZT-SKNS-1
More Details
J. Y. Siegers. et al.,
2023
PLoS Pathog
19,
(3):
e1011214
Evolution of highly pathogenic H5N1 influenza A virus in the central nervous system of ferrets
293T
MDTF
in vitro
plasmid
EZT-EVDY-1
More Details
H. Shoji. et al.,
2023
J Vet Med Sci
85,
(3):
326-328
Characterization of ferret Pit1 as a receptor of feline leukemia virus subgroup B
293T
in vitro
plasmid
EZT-EVDY-1
More Details
K. Kitao. et al.,
2023
Mol Biol Evol
40,
(5):
Dynamic Evolution of Retroviral Envelope Genes in Egg-Laying Mammalian Genomes
293T
in vitro
plasmid
EZT-EVDY-1
More Details
B. C. B. Garcia. et al.,
2023
Virus Evol
9,
(1):
vead038
The hidden diversity of ancient bornaviral sequences from X and P genes in vertebrate genomes
Hela
in vitro
plasmid
EZT-EVDY-1
More Details
S. Tsujioka. et al.,
2023
Sci Adv
9,
(26):
eadh1069
Imaging single CaMKII holoenzymes at work by high-speed atomic force microscopy
MDA-MB-231
in vitro
plasmid
EZT-EVDY-1
More Details
A. Sato. et al.,
2023
Int J Mol Sci
24,
(9):
Kallikrein-Related Peptidase 12 (KLK12) in Breast Cancer as a Favorable Prognostic Marker
silkworm
in vitro
plasmid
EZT-EVDY-1
More Details
A. Morio. et al.,
2023
Insect Biochem Mol Biol
156,
():
103936
The biological role of core 1beta1-3galactosyltransferase (T-synthase) in mucin-type O-glycosylation in Silkworm, Bombyx mori
U-2
Vero
293T
in vitro
plasmid
EZT-EVDY-1
More Details
Y. Hirai. et al.,
2023
Int J Mol Sci
24,
(7):
Nyamanini Virus Nucleoprotein and Phosphoprotein Organize Viral Inclusion Bodies That Associate with Host Biomolecular Condensates in the Nucleus
Rhesus macaque
monkey
in vivo
plasmid
EZT-VIVO-1
More Details
D. J. Hartigan-OConnor". et al.,
2023
USPTO
,
(18/055,808):
CONJUGATE POLYPEPTIDES AND VACCINES FOR INDUCING IMMUNE RESPONSES
WPMY-1
human prostate myofibroblast stromal cell
in vitro
siRNA
EZT-PRSC-1
More Details
Y. Liu. et al.,
2023
Front Pharmacol
14,
():
1105427
Inhibition of growth and contraction in human prostate stromal cells by silencing of NUAK1 and -2, and by the presumed NUAK inhibitors HTH01-015 and WZ4003
n/a
in vitro
sgRNA
dsDNA
EZT-OMNI-1
More Details
K. Tsujimoto. et al.,
2023
Embo j
42,
(1):
e111389
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6
MEF
in vitro
plasmid
EZT-MEFS-1
More Details
V. Perea. et al.,
2023
bioRxiv
,
():
Pharmacologic Activation of a Compensatory Integrated Stress Response Kinase Promotes Mitochondrial Remodeling in PERK-deficient Cells
293T
G355-5
in vitro
plasmid
EZT-EVDY-1
More Details
H. Shoji. et al.,
2023
FEBS Open Bio
13,
(3):
459-467
Potentially reduced fusogenicity of syncytin-2 in New World monkeys

The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer

Cell_1: DU 145

Cell_2: PC-3

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-DU14-1

Molecule_2:

Reagent_1: EZT-DU14-1

Reagent_2:

Author: S. Akamatsu. et al.

Year: 2015

Journal: Cell Rep

Volume: 12

Issue: 6

Mig-6 participates in the regulation of cell senescence and retinoblastoma protein phosphorylation

Cell_1: WI-38

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-WI38-1

Molecule_2:

Reagent_1: EZT-WI38-1

Reagent_2:

Author: M. Milewska. et al.

Year: 2014

Journal: Cell Signal

Volume: 26

Issue: 9

Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation

Cell_1: HEK-293T

Cell_2: Hela

Cell_3: Human fibroblast

Cell_4: hTERT RPE-1

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: J. Chang. et al.

Year: 2014

Journal: J Clin Invest

Volume: 124

Issue: 12

HnRNP C, YB-1 and hnRNP L coordinately enhance skipping of human MUSK exon 10 to generate a Wnt-insensitive MuSK isoform

Cell_1: skMC

Cell_2: KD3

Cell_3: primary human myoblasts

Cell_4: immortalized human myogenic cell

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-HSKM-1

Molecule_2:

Reagent_1: EZT-HSKM-1

Reagent_2:

Author: F. Nasrin. et al.

Year: 2014

Journal: Sci Rep

Volume: 4

Activation of proto-oncogenes by disruption of chromosome neighborhoods

Cell_1: Jurkat

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-MOLT-1

Molecule_2:

Reagent_1: EZT-MOLT-1

Reagent_2:

Author: D. Hnisz. et al.

Year: 2016

Journal: Science

Volume: 351

Issue: 6280

Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through

Cell_1: IGROV-1

Cell_2: SK-OV-3

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-IGRO-1

Molecule_2:

Reagent_1: EZT-IGRO-1

Reagent_2:

Author: L. Batista. et al.

Year: 2016

Journal: Nat Commun

Volume: 7

Vitamin D Deficiency Accelerates Coronary Artery Disease Progression in Swine

Cell_1: human preadipocyte

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-HPAD-1

Molecule_2:

Reagent_1: EZT-HPAD-1

Reagent_2:

Author: S. Chen. et al.

Year: 2016

Journal: Arterioscler Thromb Vasc Biol

Volume: 36

Issue: 8

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

Cell_1: SF268

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-S268-1

Molecule_2:

Reagent_1: EZT-S268-1

Reagent_2:

Author: C. Stein. et al.

Year: 2015

Journal: PLoS Genet

Volume: 11

Issue: 8

Metastatic melanoma cells evade immune detection by silencing STAT1

Cell_1: 1205Lu

Cell_2: Human Metastatic Melanoma Cell

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: J. L. Osborn. et al.

Year: 2015

Journal: Int J Mol Sci

Volume: 16

Issue: 2

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

Cell_1: Hela

Cell_2: BE(2)-M17

Cell_3: neurobalstoma cell

Cell_4: HEK-293T

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2: gRNA

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: C. L. Nezich. et al.

Year: 2015

Journal: J Cell Biol

Volume: 210

Issue: 3

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Cell_1: HEK-293T

Cell_2: Hela

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: M. Lazarou. et al.

Year: 2015

Journal: Nature

Volume: 524

Issue: 7565

CRACM3 regulates the stability of non-excitable exocytotic vesicle fusion pores in a Ca(2+)-independent manner via molecular interaction with syntaxin4

Cell_1: RBL-2H3

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-RBL2-1

Molecule_2:

Reagent_1: EZT-RBL2-1

Reagent_2:

Author: S. Liu. et al.

Year: 2016

Journal: Sci Rep

Volume: 6

MEIS3 is repressed in A549 lung epithelial cells by deoxynivalenol and the repression contributes to the deleterious effect

Cell_1: A549

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: T. Toyotome. et al.

Year: 2016

Journal: J Toxicol Sci

Volume: 41

Issue: 1

FAM21 directs SNX27-retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus

Cell_1: HEK-293T

Cell_2: hTERT-RPE1

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: S. Lee. et al.

Year: 2016

Journal: Nat Commun

Volume: 7

Detection of RSV Antibodies in Human Plasma by Enzyme Immunoassays

Cell_1: HEp-2

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: S. J. Jadhao. et al.

Year: 2016

Journal: Methods Mol Biol

Volume: 1442

Reep1 null mice reveal a converging role for hereditary spastic paraplegia proteins in lipid droplet regulation

Cell_1: MEF

Cell_2: mouse primary neuron

Cell_3: NIH-3T3

Cell_4: COS7

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: B. Renvoise. et al.

Year: 2016

Journal: Hum Mol Genet

Volume: 25

Issue: 23

Osteoprotegerin Promotes Cementoblastic Activity of Murine Cementoblast Cell Line in vitro

Cell_1: OCCM-30

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OCCM-1

Molecule_2:

Reagent_1: EZT-OCCM-1

Reagent_2:

Author: Y. Y. Zhang. et al.

Year: 2016

Journal: Chin J Dent Res

Volume: 19

Issue: 2

Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4

Cell_1: MRC-5

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-MRC5-1

Molecule_2:

Reagent_1: EZT-MRC5-1

Reagent_2:

Author: T. Lear. et al.

Year: 2016

Journal: J Exp Med

Volume: 213

Issue: 6

Excess Poltheta functions in response to replicative stress in homologous recombination-proficient cancer cells

Cell_1: MRC-5

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-MRC5-1

Molecule_2:

Reagent_1: EZT-MRC5-1

Reagent_2:

Author: T. Goullet de Rugy. et al.

Year: 2016

Journal: Biol Open

Volume: 5

Issue: 10

Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication

Cell_1: HDF

Cell_2: Human Dermal Fibroblast

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-HDF0-1

Molecule_2:

Reagent_1: EZT-HDF0-1

Reagent_2:

Author: R. K. Seong. et al.

Year: 2017

Journal: Immunobiology

Volume: 222

Issue: 11

STING Is Involved in Antiviral Immune Response against VZV Infection via the Induction of Type I and III IFN Pathways

Cell_1: HDF

Cell_2: MeWo melanoma cells

Cell_3: HEK-293T

Cell_4: MRC-5

Cell_5:

Cell_6:

Cell_7:

Cell_8: human fetal fibroblast

in vivo or in vitro: in vitro

Molecule_1: EZT-HDF0-1

Molecule_2:

Reagent_1: EZT-HDF0-1

Reagent_2:

Author: J. A. Kim. et al.

Year: 2017

Journal: J Invest Dermatol

Volume: 137

Issue: 10

The stoichiometry of the TMEM16A ion channel determined in intact plasma membranes of COS-7 cells using liquid-phase electron microscopy

Cell_1: COS-7

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-COS7-1

Molecule_2:

Reagent_1: EZT-COS7-1

Reagent_2:

Author: D. B. Peckys. et al.

Year: 2017

Journal: J Struct Biol

Volume: 199

Issue: 2

A conserved gating element in TRPV6 channels

Cell_1: HEK-293

Cell_2: COS-7

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-COS7-1

Molecule_2:

Reagent_1: EZT-COS7-1

Reagent_2:

Author: L. Hofmann. et al.

Year: 2017

Journal: Cell Calcium

Volume: 63

IFN-gamma promotes transendothelial migration of CD4(+) T cells across the blood-brain barrier

Cell_1: bEnd3.1

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-BEND-1

Molecule_2:

Reagent_1: EZT-BEND-1

Reagent_2:

Author: S. A. Sonar. et al.

Year: 2017

Journal: Immunol Cell Biol

Volume: 95

Issue: 9

Suppression of tumor-derived Semaphorin 7A and genetic ablation of host- derived Semaphorin 7A impairs tumor progression in a murine model of advanced breast carcinoma

Cell_1: 4T1

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-4T10-1

Molecule_2:

Reagent_1: EZT-4T10-1

Reagent_2:

Author: R. Garcia-Areas. et al.

Year: 2017

Journal: Int J Oncol

Volume: 51

Issue: 5

Macrophages promote matrix protrusive and invasive function of breast cancer cells via MIP-1beta dependent upregulation of MYO3A gene in breast cancer cells

Cell_1: Mouse

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vivo

Molecule_1: EZT-VIVO-1

Molecule_2:

Reagent_1: EZT-VIVO-1

Reagent_2:

Author: K. S. Baghel. et al.

Year: 2016

Journal: Oncoimmunology

Volume: 5

Issue: 7

High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer

Cell_1: Ishikawa

Cell_2: endometrial adenocarcinoma

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OVC8-1

Molecule_2:

Reagent_1: EZT-OVC8-1

Reagent_2:

Author: J. J. Wallbillich. et al.

Year: 2017

Journal: PLoS One

Volume: 12

Issue: 1

Dimethyl Fumarate Controls the NRF2/DJ-1 Axis in Cancer Cells: Therapeutic Applications

Cell_1: NIH:OVCAR-3

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OVC3-1

Molecule_2:

Reagent_1: EZT-OVC3-1

Reagent_2:

Author: N. E. Saidu. et al.

Year: 2017

Journal: Mol Cancer Ther

Volume: 16

Issue: 3

Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug

Cell_1: U251

Cell_2: SNB19

Cell_3: T98G

Cell_4: U87

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: Y. Dong. et al.

Year: 2017

Journal: Oncotarget

Volume: 8

Issue: 67

Cementogenesis is inhibited under a mechanical static compressive force via Piezo1

Cell_1: OCCM-30

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OCCM-1

Molecule_2:

Reagent_1: EZT-OCCM-1

Reagent_2:

Author: Y. Y. Zhang. et al.

Year: 2017

Journal: Angle Orthod

Volume: 87

Issue: 4

Small genomic insertions form enhancers that misregulate oncogenes

Cell_1: Jurkat

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-MOLT-1

Molecule_2:

Reagent_1: EZT-MOLT-1

Reagent_2:

Author: B. J. Abraham. et al.

Year: 2017

Journal: Nat Commun

Volume: 8

Intramolecular signaling in a cardiac connexin: Role of cytoplasmic domain dimerization

Cell_1: MDCK

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-MDCK-1

Molecule_2:

Reagent_1: EZT-MDCK-1

Reagent_2:

Author: A. J. Trease. et al.

Year: 2017

Journal: J Mol Cell Cardiol

Volume: 111

Folic acid modulates cancer-associated micro RNAs and inflammatory mediators in neoplastic and non-neoplastic colonic cells in a different way

Cell_1: n/a

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-HT29-1

Molecule_2:

Reagent_1: EZT-HT29-1

Reagent_2:

Author: B. Niemann. et al.

Year: 2017

Journal: Mol Nutr Food Res

Volume: 61

Issue: 12

Nell-1-DeltaE, a novel transcript of Nell-1, inhibits cell migration by interacting with enolase-1

Cell_1: OCCM-30

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OCCM-1

Molecule_2:

Reagent_1: EZT-OCCM-1

Reagent_2:

Author: H. Zhao. et al.

Year: 2018

Journal: J Cell Biochem

Volume: 119

Issue: 7

Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin- dependent Kinase 5 affects Chemo-nociception

Cell_1: Neuro-2a

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-NEUR-1

Molecule_2:

Reagent_1: EZT-NEUR-1

Reagent_2:

Author: B. E. Hall. et al.

Year: 2018

Journal: Sci Rep

Volume: 8

Issue: 1

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

Cell_1: MEF

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-MEFS-1

Molecule_2:

Reagent_1: EZT-MEFS-1

Reagent_2:

Author: J. Lebeau. et al.

Year: 2018

Journal: Cell Rep

Volume: 22

Issue: 11

Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition

Cell_1: huPASMC

Cell_2: human pulmonary artery smooth muscle cell

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-HAOS-1

Molecule_2:

Reagent_1: EZT-HAOS-1

Reagent_2:

Author: D. Zabini. et al.

Year: 2018

Journal: Am J Respir Crit Care Med

Volume: 197

Issue: 2

ARHGAP15 in Human Breast Carcinoma: A Potent Tumor Suppressor Regulated by Androgens

Cell_1: MCF-7

Cell_2: SK-BR-3

Cell_3: T47D

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: K. Takagi. et al.

Year: 2018

Journal: Int J Mol Sci

Volume: 19

Issue: 3

Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides

Cell_1: A-431

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-A431-1

Molecule_2:

Reagent_1: EZT-A431-1

Reagent_2:

Author: S. Wang. et al.

Year: 2018

Journal: Nucleic Acids Res

Volume: 46

Issue: 7

Identification of Inhibitory Ca(2+) Binding Sites in the Upper Vestibule of the Yeast Vacuolar TRP Channel

Cell_1: HEK-293

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-2930-1

Molecule_2:

Reagent_1: EZT-2930-1

Reagent_2:

Author: M. Amini. et al.

Year: 2019

Journal: iScience

Volume: 11

Autophagy, Cell Viability, and Chemoresistance Are Regulated By miR-489 in Breast Cancer

Cell_1: T47D

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-T47D-1

Molecule_2: gRNA

Reagent_1: EZT-T47D-1

Reagent_2:

Author: M. Soni. et al.

Year: 2018

Journal: Mol Cancer Res

Volume: 16

Issue: 9

Enhancing FcgammaR-mediated antibody effector function during persistent viral infection

Cell_1: GK1.5

Cell_2: hybridoma cells

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-SPAG-1

Molecule_2:

Reagent_1: EZT-SPAG-1

Reagent_2:

Author: A. Wieland. et al.

Year: 2018

Journal: Sci Immunol

Volume: 3

Issue: 27

Dimethyl fumarate is highly cytotoxic in KRAS mutated cancer cells but spares non-tumorigenic cells

Cell_1: ARPE-19

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OVC3-1

Molecule_2: siRNA

Reagent_1: EZT-OVC3-1

Reagent_2:

Author: N. E. Bennett Saidu. et al.

Year: 2018

Journal: Oncotarget

Volume: 9

Issue: 10

Identification of novel binding sites for heparin in receptor protein- tyrosine phosphatase (RPTPsigma): Implications for proteoglycan signaling

Cell_1: HEK-293

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: Y. Katagiri. et al.

Year: 2018

Journal: J Biol Chem

Volume: 293

Issue: 29

Methods for imaging mammalian mitochondrial morphology: A prospective on MitoGraph

Cell_1: HMEC-1

Cell_2: immortalized human microvascular endothelial cell

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: M. C. Harwig. et al.

Year: 2018

Journal: Anal Biochem

Volume: 552

Novel Human Polyomavirus Noncoding Control Regions Differ in Bidirectional Gene Expression according to Host Cell, Large T-Antigen Expression, and Clinically Occurring Rearrangements

Cell_1: Hs 683

Cell_2: human brain glioma fibroblast

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: E. T. Ajuh. et al.

Year: 2018

Journal: J Virol

Volume: 92

Issue: 7

LAG-3 inhibits the activation of CD4(+) T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII

Cell_1: Plat-E

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: T. Maruhashi. et al.

Year: 2018

Journal: Nat Immunol

Volume: 19

Issue: 12

Intracellular Demethylation of Methylmercury to Inorganic Mercury by Organomercurial Lyase (MerB) Strengthens Cytotoxicity

Cell_1: HEK-293

Cell_2: HeLa

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2: siRNA

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: Y. Takanezawa. et al.

Year: 2019

Journal: Toxicol Sci

Volume: 170

Issue: 2

Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury

Cell_1: SAEC

Cell_2: human small airway epithelial cell

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-HBEC-1

Molecule_2: MIr-126

Reagent_1: EZT-HBEC-1

Reagent_2:

Author: Y. Zhou. et al.

Year: 2019

Journal: Crit Care

Volume: 23

Issue: 1

Cyclin-Dependent Kinase Inhibitor 2b Mediates Excitotoxicity-Induced Death of Retinal Ganglion Cells

Cell_1: 3T3-L1

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: H. Tawarayama. et al.

Year: 2019

Journal: Invest Ophthalmol Vis Sci

Volume: 60

Issue: 13

REV7 has a dynamic adaptor region to accommodate small GTPase RAN/Shigella IpaB ligands, and its activity is regulated by the RanGTP/GDP switch

Cell_1: HEK-293

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: X. Wang. et al.

Year: 2019

Journal: J Biol Chem

Volume: 294

Issue: 43

Genetically encoded orientation probes for F-actin for fluorescence polarization microscopy

Cell_1: Hela

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: N. Nakai. et al.

Year: 2019

Journal: Microscopy (Oxf)

Volume: 68

Issue: 5

Identification of a post-transcriptional regulatory element in the human endogenous retroviral syncytin-1

Cell_1: HEK-293T

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: K. Kitao. et al.

Year: 2019

Journal: J Gen Virol

Volume: 100

Issue: 4

A NAV2729-sensitive mechanism promotes adrenergic smooth muscle contraction and growth of stromal cells in the human prostate

Cell_1: WPMY-1

Cell_2: human prostate myofibroblast stromal cell

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-PRSC-1

Molecule_2:

Reagent_1: EZT-PRSC-1

Reagent_2:

Author: Q. Yu. et al.

Year: 2019

Journal: J Biol Chem

Volume: 294

Issue: 32

N-Glycosylation is required for secretion of the precursor to brain- derived neurotrophic factor (proBDNF) carrying sulfated LacdiNAc structures

Cell_1: PC-12

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-PC12-1

Molecule_2:

Reagent_1: EZT-PC12-1

Reagent_2:

Author: J. Benicky. et al.

Year: 2019

Journal: J Biol Chem

Volume: 294

Issue: 45

Prolactin Promotes Fibrosis and Pancreatic Cancer Progression

Cell_1: PANC-1

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-PANC-1

Molecule_2:

Reagent_1: EZT-PANC-1

Reagent_2:

Author: M. Tandon. et al.

Year: 2019

Journal: Cancer Res

Volume: 79

Issue: 20

Two Vanilloid Ligand Bindings Per Channel Are Required to Transduce Capsaicin-Activating Stimuli

Cell_1: HEK-293T

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: T. Y. Liu. et al.

Year: 2019

Journal: Front Mol Neurosci

Volume: 12

Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses

Cell_1: HEK-293T

Cell_2: Plat-E

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: D. Sugiura. et al.

Year: 2019

Journal: Science

Volume: 364

Issue: 6440

Cytoplasmic DNA can be detected by RNA fluorescence in situ hybridization

Cell_1: HeLa

Cell_2: NIH-3T3

Cell_3: U-2 OS

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: E. Greenberg. et al.

Year: 2019

Journal: Nucleic Acids Res

Volume: 47

Issue: 18

Atypical motifs in the cytoplasmic region of the inhibitory immune co- receptor LAG-3 inhibit T cell activation

Cell_1: Plat-E

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: T. K. Maeda. et al.

Year: 2019

Journal: J Biol Chem

Volume: 294

Issue: 15

MDA-MB-157 Cell Line Presents High Levels of MAD2L2 and Dysregulated Mitosis

Cell_1: MDA-MB-157

Cell_2: MCF10A

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: N. Pernicone. et al.

Year: 2020

Journal: Anticancer Res

Volume: 40

Issue: 10

CDH1 binds MAD2L2 in a Rev1-like pattern

Cell_1: HEK-293

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: N. Pernicone. et al.

Year: 2020

Journal: Biochem Biophys Res Commun

Volume: 531

Issue: 4

The Biological Role of the Long Non-coding RNA LINK-A in Ovarian Carcinoma

Cell_1: OVCA433

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: N. Filippov-Levy. et al.

Year: 2020

Journal: Anticancer Res

Volume: 40

Issue: 12

The Biological and Clinical Role of the Long Non-Coding RNA LOC642852 in Ovarian Carcinoma

Cell_1: OVCAR8

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: N. Filippov-Levy. et al.

Year: 2020

Journal: Int J Mol Sci

Volume: 21

Issue: 15

METHODS AND COMPOSITIONS TO INDUCE OR SUPPRESS IMMUNE RESPONSES THROUGH THE USE OF MEMBRANE BOUND COMPLEMENT SPLIT PRODUCTS

Cell_1: Mouse

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vivo

Molecule_1: EZT-VIVO-1

Molecule_2:

Reagent_1: EZT-VIVO-1

Reagent_2:

Author: A. G. Herbert. et al.

Year: 2019

Issue: PCT / US2019 / 057993

Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16(INK4a)

Cell_1: Mouse

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vivo

Molecule_1: EZT-VIVO-1

Molecule_2:

Reagent_1: EZT-VIVO-1

Reagent_2:

Author: H. Shimoda. et al.

Year: 2019

Journal: Kidney Int

Volume: 96

Issue: 5

NOX1-derived ROS drive the expression of Lipocalin-2 in colonic epithelial cells in inflammatory conditions

Cell_1: T84

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-T840-1

Molecule_2:

Reagent_1: EZT-T840-1

Reagent_2:

Author: N. Makhezer. et al.

Year: 2019

Journal: Mucosal Immunol

Volume: 12

Issue: 1

Phospholipid phosphatase related 1 (PLPPR1) increases cell adhesion through modulation of Rac1 activity

Cell_1: Neuro-2a

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: S. Tilve. et al.

Year: 2020

Journal: Exp Cell Res

Volume: 389

Issue: 2

Gelsolin inhibits malignant phenotype of glioblastoma and is regulated by miR-654-5p and miR-450b-5p

Cell_1: U251

Cell_2: SNB19

Cell_3: T98G

Cell_4: A172

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: J. Zhang. et al.

Year: 2020

Journal: Cancer Sci

Volume: 111

Issue: 7

Ubiquitination of Src promotes its secretion via small extracellular vesicles

Cell_1: MDCK

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-MDCK-1

Molecule_2:

Reagent_1: EZT-MDCK-1

Reagent_2:

Author: K. Tanaka. et al.

Year: 2020

Journal: Biochem Biophys Res Commun

Digenic Variants in the FGF21 Signaling Pathway Associated with Severe Insulin Resistance and Pseudoacromegaly

Cell_1: L6

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-L600-1

Molecule_2:

Reagent_1: EZT-L600-1

Reagent_2:

Author: S. I. Stone. et al.

Year: 2020

Journal: J Endocr Soc

Volume: 4

Issue: 12

Nuclear envelope rupture and NET formation is driven by PKCalpha-mediated lamin B disassembly

Cell_1: HL-60

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-HL60-1

Molecule_2:

Reagent_1: EZT-HL60-1

Reagent_2:

Author: Y. Li. et al.

Year: 2020

Journal: EMBO Rep

Volume: 21

Issue: 8

The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties

Cell_1: NHBE

Cell_2: Primary normal human bronchial epithelial cell

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-HBEC-1

Molecule_2:

Reagent_1: EZT-HBEC-1

Reagent_2:

Author: K. Oniki. et al.

Year: 2020

Journal: Sci Rep

Volume: 10

Issue: 1

Efficient production of recombinant SARS-CoV-2 spike protein using the baculovirus-silkworm system

Cell_1: BmN

Cell_2: insect cell

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: R. Fujita. et al.

Year: 2020

Journal: Biochem Biophys Res Commun

Volume: 529

Issue: 2

A novel MRGPRX2-targeting antagonistic DNA aptamer inhibits histamine release and prevents mast cell-mediated anaphylaxis

Cell_1: RBL-2H3

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-RBL2-1

Molecule_2:

Reagent_1: EZT-RBL2-1

Reagent_2:

Author: Y. Suzuki. et al.

Year: 2020

Journal: Eur J Pharmacol

Volume: 878

Tachykinin-1 receptor antagonism suppresses substance-P- and compound 48/80-induced mast cell activation from rat mast cells expressing functional mas-related GPCR B3

Cell_1: RBL-2H3

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-RBL2-1

Molecule_2:

Reagent_1: EZT-RBL2-1

Reagent_2:

Author: M. N. A. Sahid. et al.

Year: 2020

Journal: Inflamm Res

Volume: 69

Issue: 3

Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses

Cell_1: MCF 10A

Cell_2: hTERT RPE-1

Cell_3: B16-F10

Cell_4: HCT116

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2: 2'3'-cGAMP

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: J. Chen. et al.

Year: 2020

Journal: Cell Rep

Volume: 32

Issue: 9

A single TRPV1 amino acid controls species sensitivity to capsaicin

Cell_1: HEK-293T

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: Y. Chu. et al.

Year: 2020

Journal: Sci Rep

Volume: 10

Issue: 1

Development of activity-based probes for the protein deacylase Sirt1

Cell_1: HEK-293T

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: C. J. Goetz. et al.

Year: 2020

Journal: Bioorg Chem

Volume: 104

Old but not obsolete: an enhanced high-speed immunoblot

Cell_1: HEK-293

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: S. L. Higashi. et al.

Year: 2020

Journal: J Biochem

Volume: 168

Issue: 3

Identification of Feline Foamy Virus-derived MicroRNAs

Cell_1: CRFK

Cell_2: Felis catus

Cell_3: cat kidney cell

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: S. Aso. et al.

Year: 2021

Journal: Microbes Environ

Volume: 36

Issue: 4

OASIS/CREB3L1 is a factor that responds to nuclear envelope stress

Cell_1: Hela

Cell_2: U-2 OS

Cell_3: U251MG

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: Y. Kamikawa. et al.

Year: 2021

Journal: Cell Death Discov

Volume: 7

Issue: 1

Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells

Cell_1: MEF

Cell_2: HEK-293

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: K. Terasawa. et al.

Year: 2021

Journal: Autophagy

Volume: 17

Issue: 12

D-2-hydroxyglutarate dehydrogenase in breast carcinoma as a potent prognostic marker associated with proliferation

Cell_1: T47D

Cell_2: MCF-7

Cell_3: MDA-MB-231

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: C. Hayashi. et al.

Year: 2021

Journal: Histol Histopathol

Volume: 36

Issue: 10

The chicken homolog of KIAA0319L functions as a receptor of avian adeno-associated virus (A3V)

Cell_1: 293T

Cell_2: CEF

Cell_3: chick embryonic fibroblast

Cell_4: LMH

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: T. Kudo. et al.

Year: 2021

Journal: The Shujitsu University journal of pharmaceutical sciences

Volume: 8

Issue: 7565

Differences in RNA and microRNA Expression Between PTCH1- and SUFU-mutated Medulloblastoma

Cell_1: Daoy

Cell_2: human brain Desmoplastic Cerebellar Medulloblastoma cell line

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: S. Gershanov. et al.

Year: 2021

Journal: Cancer Genomics Proteomics

Volume: 18

Issue: 3

Cauliflower Mosaic Virus TAV, a Plant Virus Protein That Functions like Ribonuclease H1 and is Cytotoxic to Glioma Cells

Cell_1: U251

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-U251-1

Molecule_2:

Reagent_1: EZT-U251-1

Reagent_2:

Author: V. Turri. et al.

Year: 2020

Journal: Biomed Res Int

Volume: 2020

Identification of Cathepsin D as a Plasma Biomarker for Alzheimer’s Disease

Cell_1: HeLa

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: J. W. Kim. et al.

Year: 2021

Journal: Cells

Volume: 10

Issue: 1

Primate-specific POTE-actin gene could play a role in human folliculogenesis by controlling the proliferation of granulosa cells

Cell_1: HGrC1

Cell_2: human nonluteinized granulosa cell line from human ovary

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: Y. Kasahara. et al.

Year: 2021

Journal: Cell Death Discov

Volume: 7

Issue: 1

The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules

Cell_1: Neuro-2a

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: C. Agbaegbu Iweka. et al.

Year: 2021

Journal: J Neurochem

Volume: 157

Issue: 3

The hypervariable region of atlastin-1 is a site for intrinsic and extrinsic regulation

Cell_1: NIH-3T3

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: C. M. Kelly. et al.

Year: 2021

Journal: J Cell Biol

Volume: 220

Issue: 11

Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells

Cell_1: HepG2

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: T. Nakamura. et al.

Year: 2021

Journal: Shimane Journal of Medical Science

Volume: 38

Issue: 2

CDCP1 promotes compensatory renal growth by integrating Src and Met signaling

Cell_1: MDCK

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-MDCK-1

Molecule_2:

Reagent_1: EZT-MDCK-1

Reagent_2:

Author: K. Kajiwara. et al.

Year: 2021

Journal: Life Sci Alliance

Volume: 4

Issue: 4

Leptin Is an Important Endocrine Player That Directly Activates Gonadotropic Cells in Teleost Fish, Chub Mackerel

Cell_1: BmN

Cell_2: insect cell

Cell_3: Bombyx mori-derived cell

Cell_4: Silkworm cell

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: H. Ohga. et al.

Year: 2021

Journal: Cells

Volume: 10

Issue: 12

Production of scFv, Fab, and IgG of CR3022 Antibodies Against SARS-CoV-2 Using Silkworm-Baculovirus Expression System

Cell_1: BmN

Cell_2: insect cell

Cell_3: Bombyx mori-derived cell

Cell_4: Silkworm cell

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: T. Ebihara. et al.

Year: 2021

Journal: Mol Biotechnol

Volume: 63

Issue: 12

An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation

Cell_1: 293T

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: K. Kitao. et al.

Year: 2021

Journal: Retrovirology

Volume: 18

Issue: 1

Overcoming resistance to alphaPD-1 of MMR-deficient tumors with high tumor-induced neutrophils levels by combination of alphaCTLA-4 and alphaPD-1 blockers

Cell_1: 4T1

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-4T10-1

Molecule_2:

Reagent_1: EZT-4T10-1

Reagent_2:

Author: L. Nebot-Bral. et al.

Year: 2022

Journal: J Immunother Cancer

Volume: 10

Issue: 7

Polyprenol-Based Lipofecting Agents for In Vivo Delivery of Therapeutic DNA to Treat Hypertensive Rats

Cell_1: Rat

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vivo

Molecule_1: EZT-VIVO-1

Molecule_2:

Reagent_1: EZT-VIVO-1

Reagent_2:

Author: O. Gawrys. et al.

Year: 2021

Journal: Biochem Genet

Volume: 59

Issue: 1

KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance

Cell_1: U-2 OS

Cell_2: Hela

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-U2OS-1

Molecule_2:

Reagent_1: EZT-U2OS-1

Reagent_2:

Author: S. Gaillard. et al.

Year: 2021

Journal: Biol Open

Volume: 10

Issue: 5

ADP Ribosylation Factor 6 Promotes Contraction and Proliferation, Suppresses Apoptosis and Is Specifically Inhibited by NAV2729 in Prostate Stromal Cells

Cell_1: WPMY-1

Cell_2: human prostate myofibroblast stromal cell

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-PRSC-1

Molecule_2:

Reagent_1: EZT-PRSC-1

Reagent_2:

Author: R. Wang. et al.

Year: 2021

Journal: Mol Pharmacol

Volume: 100

Issue: 4

The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II

Cell_1: THP1

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: T. Nakatani. et al.

Year: 2021

Journal: Nat Commun

Volume: 12

Issue: 1

Blimp-1 moulds the epigenetic architecture of IL-21-mediated autoimmune diseases through an autoregulatory circuit

Cell_1: EL4

Cell_2: Th0

Cell_3: polarized Th1

Cell_4: Th17

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EL40-1

Molecule_2:

Reagent_1: EZT-EL40-1

Reagent_2:

Author: Y. W. Liu. et al.

Year: 2022

Journal: JCI Insight

Chemoprevention by Microencapsulated Lactiplantibacillus Plantarum LAB12 Against Orthotopic Colorectal Cancer Mice is Associated with Apoptosis and Anti-angiogenesis

Cell_1: CT26.WT

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-CT26-1

Molecule_2:

Reagent_1: EZT-CT26-1

Reagent_2:

Author: I. M. Fareez. et al.

Year: 2022

Journal: Probiotics Antimicrob Proteins

A Role for Basigin in Toxoplasma gondii Infection

Cell_1: C8-D30

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-CRPR-1

Molecule_2:

Reagent_1: EZT-CRPR-1

Reagent_2:

Author: A. Nasuhidehnavi. et al.

Year: 2022

Journal: Infect Immun

Volume: 90

Issue: 8

IP3-dependent Ca(2+) signals are tightly controlled by Cavbeta3, but not by Cavbeta1, 2 and 4

Cell_1: COS-7

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-COS7-1

Molecule_2:

Reagent_1: EZT-COS7-1

Reagent_2:

Author: A. Belkacemi. et al.

Year: 2022

Journal: Cell Calcium

Volume: 104

Back to basics: Optimization of DNA and RNA transfer in muscle cells using recent transfection reagents

Cell_1: C2C12

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-C2C1-1

Molecule_2: siRNA

Reagent_1: EZT-C2C1-1

Reagent_2:

Author: I. Cocchiararo. et al.

Year: 2022

Journal: Exp Cell Res

Volume: 421

Issue: 2

ER proteins decipher the tubulin code to regulate organelle distribution

Cell_1: HEK-293T

Cell_2: COS-7

Cell_3: Hela

Cell_4: RPE1

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2: siRNA

Reagent_1: EZT-EVDY-1

Reagent_2: EZT-OMNI-1

Author: P. Zheng. et al.

Year: 2022

Journal: Nature

Volume: 601

Issue: 7891

Tight junction formation by a claudin mutant lacking the COOH-terminal PDZ domain-binding motif

Cell_1: HEK-293

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: S. Fujiwara. et al.

Year: 2022

Journal: Ann N Y Acad Sci

Volume: 1516

Issue: 1

TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties

Cell_1: Hela

Cell_2: A549

Cell_3: MCF7

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: N. Funato. et al.

Year: 2022

Journal: Sci Rep

Volume: 12

Issue: 1

Visualization of osteocalcin and bone morphogenetic protein 2 (BMP2) secretion from osteoblastic cells by bioluminescence imaging

Cell_1: MC3T3-E1

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: H. Sugimoto. et al.

Year: 2022

Journal: Biochem Biophys Res Commun

Volume: 635

Exosome Secretion and Epithelial-Mesenchymal Transition in Ovarian Cancer Are Regulated by Phospholipase D

Cell_1: OVCAR3

Cell_2: OVCAR8

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: H. Onallah. et al.

Year: 2022

Journal: Int J Mol Sci

Volume: 23

Issue: 21

Characterization of a Novel Heterochromatin Protein 1 Homolog HP1c” in the Silkworm, Bombyx mori”

Cell_1: silkworm

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: M. Hino. et al.

Year: 2022

Journal: Insects

Volume: 13

Issue: 7

Construction of gene co-expression networks in cultured silkworm cells and identification of previously uncharacterized lepidopteran-specific genes required for chromosome dynamics

Cell_1: silkworm

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: H. Mon. et al.

Year: 2022

Journal: Insect Biochem Mol Biol

Volume: 151

XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation

Cell_1: HMLE

Cell_2: HMEC

Cell_3: Human mammary epithelial cell

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-HMEC-1

Molecule_2:

Reagent_1: EZT-HMEC-1

Reagent_2:

Author: L. Richart. et al.

Year: 2022

Journal: Cell

Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension

Cell_1: HL-60

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-HL60-1

Molecule_2:

Reagent_1: EZT-HL60-1

Reagent_2:

Author: S. Taylor. et al.

Year: 2022

Journal: Am J Respir Crit Care Med

NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides

Cell_1: Hepa 1-6

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-HEPA-1

Molecule_2:

Reagent_1: EZT-HEPA-1

Reagent_2:

Author: L. Zhang. et al.

Year: 2022

Journal: Nucleic Acid Ther

Volume: 32

Issue: 4

SETDB1 regulates microtubule dynamics

Cell_1: B16-F1

Cell_2: WM266.4

Cell_3: HeLa

Cell_4: HEK-293

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: R. Hernandez-Vicens. et al.

Year: 2022

Journal: Cell Prolif

Volume: 55

Issue: 12

Silkworm FoxL21 plays important roles as a regulator of ovarian development in both oogenesis and ovariole development

Cell_1: BmN4-SID1

Cell_2: Bombyx mori

Cell_3: Silk moth

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: M. Tanaka. et al.

Year: 2022

Journal: Insect Biochem Mol Biol

Volume: 143

Genetic and biological characterization of feline foamy virus isolated from a leopard cat (Prionailurus bengalensis) in Vietnam

Cell_1: CRFK

Cell_2: Felis catus

Cell_3: cat kidney cell

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: A. Sumiyoshi. et al.

Year: 2022

Journal: J Vet Med Sci

Volume: 84

Issue: 1

Disrupting the MAD2L2-Rev1 Complex Enhances Cell Death upon DNA Damage

Cell_1: HEK-293

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: N. Pernicone. et al.

Year: 2022

Journal: Molecules

Volume: 27

Issue: 3

N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic beta- cells

Cell_1: INS 832/13

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: J. A. Nord. et al.

Year: 2022

Journal: Front Endocrinol (Lausanne)

Volume: 13

A novel cytoskeletal action of xylosides

Cell_1: Neuro-2a

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: C. P. Mencio. et al.

Year: 2022

Journal: PLoS One

Volume: 17

Issue: 6

PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity

Cell_1: Plat-E

Cell_2: HEK-293T

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: D. Sugiura. et al.

Year: 2022

Journal: Nat Immunol

Volume: 23

Issue: 3

Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia

Cell_1: U-2 OS

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: D. J. Byrne. et al.

Year: 2022

Journal: Acta Neuropathol Commun

Volume: 10

Issue: 1

Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis

Cell_1: L6

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-L600-1

Molecule_2:

Reagent_1: EZT-L600-1

Reagent_2:

Author: K. E. Merz. et al.

Year: 2022

Journal: Front Endocrinol (Lausanne)

Volume: 13

Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1

Cell_1: L6

Cell_2: skeletal muscle myoblast

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-L600-1

Molecule_2:

Reagent_1: EZT-L600-1

Reagent_2:

Author: K. E. Merz. et al.

Year: 2022

Journal: Nat Commun

Volume: 13

Issue: 1

The mechanism of STING autoinhibition and activation

Cell_1: n/a

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: n/a

Molecule_2:

Reagent_1: n/a

Reagent_2:

Author: S. Liu. et al.

Year: 2023

Journal: Mol Cell

Volume: 83

Issue: 9

Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site

Cell_1: U251

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-U251-1

Molecule_2:

Reagent_1: EZT-U251-1

Reagent_2:

Author: C. H. Lipper. et al.

Year: 2022

Journal: Structure

Volume: 30

Issue: 2

Protein Kinase CK2 Acts as a Molecular Brake to Control NADPH Oxidase 1 Activation and Colon Inflammation

Cell_1: T84

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-T840-1

Molecule_2:

Reagent_1: EZT-T840-1

Reagent_2:

Author: D. Liu. et al.

Year: 2022

Journal: Cell Mol Gastroenterol Hepatol

Volume: 13

Issue: 4

miR-489 Confines Uncontrolled Estrogen Signaling through a Negative Feedback Mechanism and Regulates Tamoxifen Resistance in Breast Cancer

Cell_1: T47D

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-T47D-1

Molecule_2: gRNA

Reagent_1: EZT-T47D-1

Reagent_2:

Author: M. Soni. et al.

Year: 2022

Journal: Int J Mol Sci

Volume: 23

Issue: 15

Mutation of the proline P81 into a serine modifies the tumour suppressor function of the von Hippel-Lindau gene in the ccRCC

Cell_1: 786-O

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: F. Chesnel. et al.

Year: 2022

Journal: Br J Cancer

Volume: 127

Issue: 11

Switching of Photocatalytic Tyrosine/Histidine Labeling and Application to Photocatalytic Proximity Labeling

Cell_1: HeLa

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: K. Nakane. et al.

Year: 2022

Journal: Int J Mol Sci

Volume: 23

Issue: 19

Structural studies of human fission protein FIS1 reveal a dynamic region important for GTPase DRP1 recruitment and mitochondrial fission

Cell_1: HMEC-1

Cell_2: ARPE–19

Cell_3: HeLa

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2:

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: J. M. Egner. et al.

Year: 2022

Journal: J Biol Chem

Volume: 298

Issue: 12

p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS

Cell_1: U251MG

Cell_2: U87MG

Cell_3: NP5

Cell_4: LN229

Cell_5:

Cell_6:

Cell_7:

Cell_8: fibroblast

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: A. Saito. et al.

Year: 2023

Journal: Cell Rep

Volume: 42

Issue: 5

Evolution of highly pathogenic H5N1 influenza A virus in the central nervous system of ferrets

Cell_1: A549

Cell_2: SK-N-SH

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-A549-1

Molecule_2:

Reagent_1: EZT-A549-1

Reagent_2: EZT-SKNS-1

Author: J. Y. Siegers. et al.

Year: 2023

Journal: PLoS Pathog

Volume: 19

Issue: 3

Characterization of ferret Pit1 as a receptor of feline leukemia virus subgroup B

Cell_1: 293T

Cell_2: MDTF

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: H. Shoji. et al.

Year: 2023

Journal: J Vet Med Sci

Volume: 85

Issue: 3

Dynamic Evolution of Retroviral Envelope Genes in Egg-Laying Mammalian Genomes

Cell_1: 293T

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: K. Kitao. et al.

Year: 2023

Journal: Mol Biol Evol

Volume: 40

Issue: 5

The hidden diversity of ancient bornaviral sequences from X and P genes in vertebrate genomes

Cell_1: 293T

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: B. C. B. Garcia. et al.

Year: 2023

Journal: Virus Evol

Volume: 9

Issue: 1

Imaging single CaMKII holoenzymes at work by high-speed atomic force microscopy

Cell_1: Hela

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: S. Tsujioka. et al.

Year: 2023

Journal: Sci Adv

Volume: 9

Issue: 26

Kallikrein-Related Peptidase 12 (KLK12) in Breast Cancer as a Favorable Prognostic Marker

Cell_1: MDA-MB-231

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: A. Sato. et al.

Year: 2023

Journal: Int J Mol Sci

Volume: 24

Issue: 9

The biological role of core 1beta1-3galactosyltransferase (T-synthase) in mucin-type O-glycosylation in Silkworm, Bombyx mori

Cell_1: silkworm

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: A. Morio. et al.

Year: 2023

Journal: Insect Biochem Mol Biol

Volume: 156

Nyamanini Virus Nucleoprotein and Phosphoprotein Organize Viral Inclusion Bodies That Associate with Host Biomolecular Condensates in the Nucleus

Cell_1: U-2

Cell_2: Vero

Cell_3: 293T

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: Y. Hirai. et al.

Year: 2023

Journal: Int J Mol Sci

Volume: 24

Issue: 7

CONJUGATE POLYPEPTIDES AND VACCINES FOR INDUCING IMMUNE RESPONSES

Cell_1: Rhesus macaque

Cell_2: monkey

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vivo

Molecule_1: EZT-VIVO-1

Molecule_2:

Reagent_1: EZT-VIVO-1

Reagent_2:

Author: D. J. Hartigan-OConnor". et al.

Year: 2023

Journal: USPTO

Issue: 18/055,808

Inhibition of growth and contraction in human prostate stromal cells by silencing of NUAK1 and -2, and by the presumed NUAK inhibitors HTH01-015 and WZ4003

Cell_1: WPMY-1

Cell_2: human prostate myofibroblast stromal cell

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-PRSC-1

Molecule_2:

Reagent_1: EZT-PRSC-1

Reagent_2:

Author: Y. Liu. et al.

Year: 2023

Journal: Front Pharmacol

Volume: 14

The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6

Cell_1: n/a

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-OMNI-1

Molecule_2: dsDNA

Reagent_1: EZT-OMNI-1

Reagent_2:

Author: K. Tsujimoto. et al.

Year: 2023

Journal: Embo j

Volume: 42

Issue: 1

Pharmacologic Activation of a Compensatory Integrated Stress Response Kinase Promotes Mitochondrial Remodeling in PERK-deficient Cells

Cell_1: MEF

Cell_2:

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-MEFS-1

Molecule_2:

Reagent_1: EZT-MEFS-1

Reagent_2:

Author: V. Perea. et al.

Year: 2023

Journal: bioRxiv

Potentially reduced fusogenicity of syncytin-2 in New World monkeys

Cell_1: 293T

Cell_2: G355-5

Cell_3:

Cell_4:

Cell_5:

Cell_6:

Cell_7:

Cell_8:

in vivo or in vitro: in vitro

Molecule_1: EZT-EVDY-1

Molecule_2:

Reagent_1: EZT-EVDY-1

Reagent_2:

Author: H. Shoji. et al.

Year: 2023

Journal: FEBS Open Bio

Volume: 13

Issue: 3

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