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IgG1 Fc Protein, Human
Catalog Number: EZC-IG1-H2
Synonym: Fc, IgG1 Fc, IgG Fc
Source: Recombinant human IgG1 Fc (rhIgG1 Fc) Glu99 - Lys330 (Accession # AAC82527.1) was expressed in human 293 cells (HEK293).
Molecular Characterization: rhIgG1 Fc, a 232 amino acids protein, has a calculated MW of 26 kDa. DTT-reduced protein migrates as 35 kDa protein due to glycosylation.
Purity: >98% as determined by SDS-PAGE of 20 g reduced rhIgG1 Fc. All lots are greater than 98% pure.
Endotoxin: Less than 1.0 EU per 0.5g of the human IgG1 Fc by the LAL method.
Formulation: Bulk protein in a 0.22 m filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder.Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
Storage: Store at -20? in lyophilized state after receipt. For long term storage, upon reconstitution rhIgG1 Fc should be aliquot and store at -20? or -80?. Avoid repeated freeze-thaw cycles.
Background: Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.(1)
      Research Use Only. Not for use in diagnostic or therapeutic procedures.
Purchase This Product
  Size Price Number
  200 g $364.00
  1 mg $840.00
(1) Medinger M, Tzankov A,et al.( 2010), J Clin Immunol. 30 Suppl 1:S9-14.
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