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ALK-6 / BMPR1B (Bone Morphogenetic Protein Receptor 1B), Human
Catalog Number: EZC-BMB-H1
Synonym: BMPR-1B, BMPR1B, BMPRIB, BMPR-IB, ALK-6, ALK6, CDw293, Bone morphogenetic protein receptor type-1B
Source: Bone morphogenetic protein receptor,type IB (rhBMPR1B or rhALK6), Lys14-Arg126(Accession # O00238) was expressed in HEK 293
Molecular Characterization: rhALK6 contains C-terminal polyhistidine tag and has a calculated MW of 13.5 kDa. DTT-reduced protein migrates as 20 kDa protein due to glycosylation.
Purity: >97% purity as determined by SDS-PAGE of reduced rhALK6.
Endotoxin: Less than 0.01 ng endotoxin per g rhALK6.
Formulation: Bulk protein in a 0.22 m filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
Storage: Store at -20? in lyophilized state after receipt. For long term storage, upon reconstitution rhALK6 should be aliquot and store at -20? or -80?. Avoid repeated freeze-thaw cycles.
Background: The bone morphogenetic protein receptor, type IB also known as BMPR1B or ALK6 is a protein which in humans is encoded by the BMPR1B gene. Bone morphogenetic proteins (BMPs) signal through the BMP type I and type II receptors to regulate cellular processes, including embryonic development. The type I BMP receptors activin-like kinase (ALK)3 and ALK6 share a high degree of homology, yet possess distinct signaling roles(1). Decreased expression of BMPR-IB correlates with poor prognosis in breast cancer patients and leads to increased cell proliferation of breast cancer cells in vitro, and BMPR-IB mediates an inhibitory effect on breast cancer cells (2). Researchers found that BMP-2-induced apoptosis was mediated by BMP-RIB in osteoblasts and occurred independently of BMP-2-induced osteoblast differentiation(3).
      Research Use Only. Not for use in diagnostic or therapeutic procedures.
Purchase This Product
  Size Price Number
  50 g $364.00
  1 mg $2,820.00
Reference
(1) Lee NY, Kirkbride KC, et al.(2009). Mol Biol Cell. 20(20):4362-70 (2) Bokobza SM, Ye L, et al. (2009). Cancer Genomics Proteomics .6(2):101-8. (3) Ha E, Lemonnier J, et al.(2004). J Biol Chem. 16;279(3):1650-8
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