Categories
Recombinant Proteins
Growth Factors and Cytokines
Receptors
CD Antigens
Affinity Ligands
Other Proteins
Transfection Reagents
For Cell Lines
For Primary Cells
DPP4 / CD26 (Dipeptidyl peptidase-4), Human
Catalog Number: EZC-DP4-H1
Synonym: DPP4, DPP-4, ADABP, ADCP2, ADCP-2, CD26, CD-26, DPPIV, DPPIV, TP103, TP-103
Source: Recombinant human DPPIV/CD26/DPP4 (rhDPPIV) Asn 29 - Pro 766 (Accession # NP_001926.2) was produced in human HEK293 cells.
Molecular Characterization: rhDPPIV, with two amino acids (Gly-Pro) at the N- terminus has a calculated MW of 85.4 kDa expressed. Protein migrates as 95 kDa in reduced SDS-PAGE resulting from glycosylation.
Purity: >95% as determined by SDS-PAGE. All lots are greater than 95% pure.
Endotoxin: Less than 1.0 EU per 1 g of the rhDPPIV by the LAL method.
Formulation: Bulk protein in a 0.22 m filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
Storage: Store at -20? in lyophilized state after receipt. For long term storage, upon reconstitution rhDPPIV should be aliquot and store at -20? or -80?. Avoid repeated freeze-thaw cycles.
Background: Dipeptidyl peptidase-IV (DPPIV), also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides.(1) The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides.(2) DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1.(3) DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.(4) DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.
      Research Use Only. Not for use in diagnostic or therapeutic procedures.
Purchase This Product
  Size Price Number
  50 g $640.00
  1 mg $4,500.00
Reference
(1) Kameoka J, et al.,1993, Science, 261 (5120): 466-9. (2) Chen X, 2006, Adv. Exp. Med. Biol. 575: 2732. (3) Morimoto, C. et al., 1994, Proc. Natl. Acad. Sci. USA. 91: 9960-4 (4) Havre PA, et al., 2008, Front. Biosci. 13: 163445
EZ Biosystems LLC. All Right Reserved