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CNTN2 (Contactin-2), Human
Catalog Number: EZC-CN2-H1
Synonym: CNTN2, CNTN-2, AXT, DKFZp781D102, FLJ37193, FLJ42746, MGC157722, TAG-1, TAG1, TAX, TAX1, TAX-1, Contactin-2
Source: Recombinant human CNTN2 (rhCNTN2) Ser31-Asn 1012 (Accession # NP_005067.1) fused with a C-terminal his tag was produced in human HEK293 cells.
Molecular Characterization: rhCNTN2 was fused with 6his tag at the C-terminal and has a calculated MW of 109 kDa expressed. The predicted N-terminal is Ser 31. Protein migrates as 140 kDa in reduced SDS-PAGE resulting from glycosylation.
Purity: >95% as determined by SDS-PAGE. All lots are greater than 95% pure.
Endotoxin: Less than 1.0 EU per 1 g of the rhCNTN2 by the LAL method.
Formulation: Bulk protein in a 0.22 m filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder. Normally 2-7% trehalose and mannitol are added as protectants before lyophilization.
Storage: Store at -20? in lyophilized state after receipt. For long term storage, upon reconstitution rhCNTN2 should be aliquot and store at -20? or -80?. Avoid repeated freeze-thaw cycles.
Background: CNTN2 also known as Contactin-2, TAX1 (transiently-expressed axonal glycoprotein), TAG1 (transient axonal glycoprotein), and axonin-1, and is a member of the immunoglobulin superfamily. CNTN2 consists of six Ig-like domains and four fibronectin type III domains, and is anchored to the membrane by glycosylphosphatidylinositol (GPI), whereas the soluble form can be released by a GPI-specific phospholipase. As a neural cell adhesion molecule expressed by a subset of neuronal populations in the developing CNS and PNS, CNTN2 mediates cell-cell interactions either via homophilic, or heterophilic contacts with various adhesion molecules including NgCAM, NrCAM, NCAM and neurocan. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.[1-3]
      Research Use Only. Not for use in diagnostic or therapeutic procedures.
Purchase This Product
  Size Price Number
  100 g $583.00
  1 mg $2,610.00
Reference
(1) Tsiotra PC, et al., 1993, Genomics 18 (3): 5627. (2) Traka, M. et al., 2003, J. Cell. Biol. 162: 1161-1172. (3) Mrtl M, ET AL., 2007, Protein Sci.16(10):2174-83.
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