Recombinant Proteins
Growth Factors and Cytokines
CD Antigens
Affinity Ligands
Other Proteins
Transfection Reagents
For Cell Lines
For Primary Cells
CD155 / PVR, Human
Catalog Number: EZC-CD5-H1
Synonym: PVR, FLJ25946, PVS, CD155, TAGE4, HVED, NECL5, cluster of differentiation 155
Source: Recombinant human CD155/PVR (rhCD155) Trp21- Asn 343 (Accession # NP_006496.2 ) fused with a C-terminal 6-His tag was produced in human HEK293 cells.
Molecular Characterization: rhCD155 was fused with a C-terminal 6His tag and has a calculated MW of 28 kDa KDa. The predicted N-terminal is Trp21. DTT-reduced protein migrates as 50-65 kDa polypeptide in SDS-PAGE resulting from glycosylation.
Purity: >95% as determined by SDS-PAGE. All lots are greater than 95% pure.
Endotoxin: Less than 1.0 EU per 1 g of the rhFollistatin by the LAL method.
Formulation: Bulk protein in a 0.22 m filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder.Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
Storage: Store at -20? in lyophilized state after receipt. For long term storage, upon reconstitution rhFollistatin should be aliquot and store at -20? or -80?. Avoid repeated freeze-thaw cycles.

CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily.[1] Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells.[2]CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells [1-3]. The fulllength (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N terminal V type and two C2 type Ig like domains [1-3].CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus.[4] Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy[1] while a high resolution structures of theectodomain D1 and D2 of CD155 were solved by x-ray crystallography.[4]

      Research Use Only. Not for use in diagnostic or therapeutic procedures.
Purchase This Product
  Size Price Number
  100 g $465.00
  1 mg $2,610.00

(1) Mendelsohn CL, Wimmer E, Racaniello VR (1989) Cell 56 (5): 85565 (2) Maier MK, Seth S, Czeloth N, et al. (2007). European Journal of Immunology(8): 2214 (3) Koike, H. et al. (1990) EMBO J. 9:3217 (4) Zhang P, Mueller S, Morais MC. Proc. Natl. Acad. Sci. U.S.A. 105 (47): 18284

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